Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis

•Data support EEG as an important tool to measure delirium-relevant aspects in mice.•During critical illness mice showed slow-wave EEG dominance and sleep disruption.•Hypersensitivity to auditory stimuli during sepsis can be measured in sick mice.•Cognitive disruption was observed in some mice following recovery from systemic inflammation.•Deficits post sepsis associated with altered hippocampal long term potentiation.