A homozygous truncating mutation of FGL2 is associated with immune dysregulation.

Erin Janssen,Mohammad F Alosaimi,Anas M Alazami, Abdullah Alsuliman,Ayodele Alaiya,Bandar Al-Saud,Hamoud Al-Mousa, Tariq Jassim Al-Zaid,Emma Smith,Craig D Platt,Hibah Alruwaili,Sarah Albanyan,Sulaiman M Al-Mayouf,Raif S Geha

The Journal of allergy and clinical immunology（2023）

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摘要

We identified a homozygous mutation in FGL2 in a patient with immune dysregulation and impaired Treg cell function. Soluble FGL2 rescued the Treg cell defect, suggesting that it may provide a useful therapy for the patient.

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关键词

FGL2,immune dysregulation,regulatory T cells

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