Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

Med（2022）

引用 23|浏览29

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摘要

•CISH is associated with non-functional tumor-infiltrating lymphocytes (TIL)•CISH KO uncovers TIL neoantigen reactivity•CISH KO induces hyper-activation but not hyper-maturation•Cish KO synergizes with PD1 blockade in vivo

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关键词

CRISPR,checkpoint,scRNAseq,neoantigen,TIL,PD-1,immunotherapy,T cell therapy,cancer,CISH

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