CCL2 recruits fetal microchimeric cells and dampens maternal brain damage in post-partum mice

Maria Sbeih,Bénédicte Oulès,Mansour Alkobtawi,Leslie Schwendimann,Qui Trung Ngô,Romain Fontaine,Natacha Teissier,Pierre Gressens,Sélim Aractingi

Neurobiology of Disease（2022）

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摘要

Preventing brain cell loss and enhancing tissue repair are crucial objectives to improve the outcome of stroke. Fetal microchimerism has been implicated in brain repair following ischemic stroke in mice. CCL2/CCR2 signaling pathway triggers fetal progenitors trafficking to cutaneous wounds. Therefore, we sought to evaluate whether CCL2 could dampen brain damage in a model of excitotoxic lesion in post-partum mice.

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关键词

Fetal microchimeric cells,Excitotoxic brain damage,Post-partum,CCL2,Brain repair,Stem cells

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