Angelica oil restores the intestinal barrier function by suppressing S100A8/A9 signalling in mice with ulcerative colitis

•Angelica oil protected intestinal mucosal barrier damage in mice with ulcerative colitis.•Angelica oil regulated macrophage and neutrophil activation and suppresses inflammatory cytokine production.•S100A8/A9 aggravated intestinal mucosal inflammatory injury.•Angelica oil protected intestinal mucosal barrier by inhibiting S100A8/A9-mediated inflammatory signalling pathway via regulating macrophage and neutrophil activation.