Sensitivity of wastewater surveillance: What is the minimum COVID-19 cases required in population for SARS-CoV-2 RNA to be detected in wastewater?

Wastewater surveillance,also referred to as wastewater-based surveillance(WBS)and wastewater-based epidemiology(WBE),has become a powerful tool for the monitoring,con-trol,and prevention of infectious diseases,including COVID-19.Wastewater surveillance is a complementary and unbi-ased approach to evaluate disease burden at a population level(Hrudey et al.,2022;Kitajima et al.,2020;Kumblathan et al.,2021;Polo et al.,2020).