Mitochondria targeted liposomes of metformin for improved anticancer activity: Preparation and evaluation

In recent times, mitochondria have emerged as an effective target for treatment of cancer because of their prominent role in maintaining cellular homeostasis. Metformin hydrochloride (MET), an antidiabetic drug has been reported to be effective against several types of cancers, primarily by acting on mitochondria. So, enabling mitochondria targeted delivery of MET could be an effective strategy for successful chemotherapy. Objective of the study was to develop mitochondria targeted liposomes (Mito-liposomes) of MET for improved therapy of cancer and thereby enable its repurposing for treatment of cancer.