Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze.

Débora Fabris,Milene C Carvalho,Marcus L Brandão,Wiliam A Prado,Antônio W Zuardi,José A Crippa,Amanda R de Oliveira,Thelma A Lovick,Karina Genaro

Journal of psychopharmacology (Oxford, England)（2022）

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摘要

We suggest that there are sex differences in the anxiolytic-like effects of CBD in rats that reflect different underlying mechanisms: based on literature data, gonadal hormone status linked to GABA receptor expression in females, and 5-HT receptor activation in males.

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关键词

Cannabidiol,anxiety,defensive behavior,diestrus,proestrus,sex differences

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