Gut microbiota-derived succinate aggravates acute lung injury after intestinal ischaemia/reperfusion in mice.

Yi-Heng Wang,Zheng-Zheng Yan,Si-Dan Luo,Jing-Juan Hu,Mei Wu,Jin Zhao,Wei-Feng Liu,Cai Li,Ke-Xuan Liu

The European respiratory journal（2023）

引用 10|浏览8

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摘要

Gut microbiota-derived succinate exacerbates intestinal I/R-induced ALI through SUCNR1-dependent alveolar macrophage polarisation, identifying succinate as a novel target for gut-derived ALI in critically ill patients.

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关键词

intestinal ischaemia/reperfusion,succinate,acute lung injury,microbiota-derived

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