circSMAD4 Promotes Experimental Colitis and Impairs Intestinal Barrier Functions by Targeting Janus Kinase 2 Through Sponging miR-135a-5p.

Jie Zhao,Zhiliang Lin,Pu Ying,Zhibin Zhao,Haojun Yang,Jun Qian,Yu Gong,Yan Zhou,Yi Dai,Yuwen Jiao,Weiming Zhu,Honggang Wang,Liming Tang

Journal of Crohn's & colitis（2023）

引用 3|浏览7

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摘要

This study shows that circSMAD4 regulates the progression of experimental colitis via the miR-135a-5p/JAK2 signalling axis and it may be a potential therapeutic target.

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关键词

Crohn’s disease,JAK2,circSMAD4,colitis,intestinal barrier function,miR-135a-5p

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