The immunomodulatory functions of chromogranin A-derived peptide pancreastatin

Melina Ioannidis,Sushil K. Mahata,Geert van den Bogaart

Peptides（2022）

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摘要

Chromogranin A (CgA) is a 439 amino acid protein secreted by neuroendocrine cells. Proteolytic processing of CgA results in the production of different bioactive peptides. These peptides have been associated with inflammatory bowel disease, diabetes, and cancer. One of the chromogranin A-derived peptides is ∼52 amino acid long Pancreastatin (PST: human (h)CgA250–301, murine (m)CgA263–314). PST is a glycogenolytic peptide that inhibits glucose-induced insulin secretion from pancreatic islet β-cells. In addition to this metabolic role, evidence is emerging that PST also has inflammatory properties. This review will discuss the immunomodulatory properties of PST and its possible mechanisms of action and regulation. Moreover, this review will discuss the potential translation to humans and how PST may be an interesting therapeutic target for treating inflammatory diseases.

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关键词

PST,PSTNΔ3,PSTCΔ8,CgA,, human: CHGA, mouse: Chga,h,m,r,p,CST,CgA-KO,CST-KO,ELISA,Asn,Ala,Arg,ARG1,b,DSS,DIO,FITC-dextran,Gly,Glu,GRP78,G6pc, mouse gene: G6pc,Pck1, mouse gene: Pck1,IFN-γ,IL-,LPS,NF-κΒ,PBMC,PC,PKC,Ser,TNF-α,Tyr,Thr,Trp,Val,IRS,IL-4R,JAK,STAT 6,GLP-1,moDCs

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