Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.

Mohamad Saad,Ayman El-Menyar,Khalid Kunji,Ehsan Ullah,Jassim Al Suwaidi,Iftikhar J Kullo

Circulation. Genomic and precision medicine（2022）

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摘要

Overall, we demonstrate that PRSs derived from European ancestry genome-wide association studies performed well in a Middle Eastern cohort, suggesting these could be used in the clinical setting while ancestry-specific PRSs are developed.

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关键词

Middle East,coronary heart disease,diverse populations,polygenic risk score,precision medicine,whole genome sequencing

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