Unsaturated Fatty Acid 10H2DA Content in Serbian Royal Jelly and Its Effects on Motility of Colorectal Carcinoma Cell Lines

Royal jelly (RJ) is natural bee product with multiple medicinal properties that have been mainly attributed to its active compound fatty acid 10H2DA. Herein, we determined its content in RJ sampled in Serbia, and analyzed its anti-migratory activity on colorectal carcinoma cells. This is the first report of the 10H2DA concentration in Serbian RJ, which is 0.92%. This acid was potent in inhibiting the motility of very aggressive HCT-116 cell line in dose-dependent manner. Further studies are needed to be conducted, especially more detailed research regarding application of this natural product compound as complementary drug in anti-cancer treatment.