Alkyltriphenylphosphonium Turns Naphthoquinoneimidazoles Into Potent Membrane Depolarizers Against Mycobacteria

Kevin Timothy Fridianto,Gregory Adrian Gunawan,Kiel Hards,Jickky Palmae Sarathy,Gregory M Cook,Thomas Dick,Mei Lin Go,Yulin Lam

RSC Medicinal Chemistry（2022）

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摘要

Due to its central role in energy generation and bacterial viability, mycobacterial bioenergetics is an attractive therapeutic target for anti-tuberculosis drug discovery. Building upon our work on antimycobacterial dioxonaphthoimidazoliums that...

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naphthoquinoneimidazoles,potent membrane depolarizers

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