Peripheral Polyfunctional PD1 ⁺ CD8 ⁺ T cells demonstrated strong immune protection in Non‐small Cell Lung Cancer

Higher frequencies of polyfunctional PD1+ CD8+ T cells exhibited a stronger capacity to kill tumor cells in vitro and in vivo experiments. These results suggested that peripheral polyfunctional PD1+ CD8+ T cells demonstrated strong immune protection. This study also provided a potential combined treatment strategy with anti-PD1 and CAR-T therapy.