UCP1 Alleviates Renal Interstitial Fibrosis Progression Through Oxidative Stress Pathway Mediated by SIRT3 Protein Stability

Wei Xiong,Zhiyong Xiong,Anni Song,Chuntao Lei,Chen Ye,Hua Su,Chun Zhang

Social Science Research Network（2022）

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摘要

Elevating the expression of UCP1 can inhibit the occurrence of oxidative stress by stabilizing SIRT3, thereby reducing EMT and ECM accumulation, and ultimately alleviating renal interstitial fibrosis. It will provide new instructions and targets for the treatment of CKD.

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UCP1 Alleviates Renal Interstitial Fibrosis Progression Through Oxidative Stress Pathway Mediated by SIRT3&nbsp;Protein Stability

UCP1 Alleviates Renal Interstitial Fibrosis Progression Through Oxidative Stress Pathway Mediated by SIRT3 Protein Stability