Crucial epigenetic modules in skin differentiation

Tissue homeostasis is directed by temporal-spatial regulation of gene expression, where lineage specification is a critical step, requiring precise expression profiles. Epigenetic regulation and chromatin accessibility play a major role in ensuring adequate regulation of transcriptional machinery. We amalgamated data from RNA-Seq, ATAC-Seq, ChIP-Seq and HiC to gain transcriptomic/chromatin profile of distinct skin epidermal layers. The data was generated from basal (proliferating) and suprabasal (differentiated) cells of mouse neonate skin epidermis.