Dopamine Synthesis Capacity and GABA and Glutamate Levels Separate Antipsychotic-Naïve Patients With First-Episode Psychosis From Healthy Control Subjects in a Multimodal Prediction Model
Biological psychiatry global open science(2023)
摘要
Our multimodal approach proved superior classification accuracy, implying that the pathophysiology of patients represents a combination of neurotransmitter disturbances rather than aberrations in a single neurotransmitter. Particularly aberrant interrelations between K in the nucleus accumbens and GABA values in the ACC appeared to contribute diagnostic information.
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关键词
1HMRS,18F-FDOPA PET,Antipsychotic-naïve,Dopamine,First-episode psychosis,GABA,Glx,schizophrenia
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