Serotonergic Neurotransmission in Limbic Regions May Reflect Therapeutic Response of Depressive Patients: A PET Study with 11C-WAY-100635 and 18F-MPPF

Soichiro Kitamura,Yasuyuki Kimura,Keisuke Takahata,Sho Moriguchi,Manabu Kubota,Hitoshi Shimada,Hironobu Endo,Yuhei Takado,Kazunori Kawamura,Ming-Rong Zhang,Tetsuya Suhara,Makoto Higuchi

Social Science Research Network（2022）

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摘要

These results suggest a diversity of antidepressant-induced extracellular 5-HT elevations in the limbic system among depressive patients, which is associated with the individual variability of clinical symptoms following the treatment.

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关键词

Depression, positron emission tomography, C-11-WAY-100635, F-18-MPPF, limbic lobe

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