Acceleration of bone formation by octacalcium phosphate composite in a rat tibia critical-sized defect

Journal of Orthopaedic Translation(2022)

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摘要
In our research, we compared our various manufactured OCP composites to commercially available β-TCP in critical-defect rat tibia model. OCP/Col showed acceleration in hole-defect model as previous studies in dental field but in our critical-sized defect model it resorbed fast without acceleration of bony union. OCP/Alg showed matched results compared to β-TCP and relatively fast resorption so we showed market value in special clinical indication depending on treatment strategy. This is the first OCP composite study in orthopaedics with animal critical-sized tibia bone study and further study should be considered for clinical application based on this study.
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关键词
Octacalcium phosphate,β-tricalcium phosphate,Bone regeneration,Bone substitute,Critical-sized defect
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