Po-616-08 mechanisms of immune-mediated injury in arrhythmogenic cardiomyopathy

Inhibition of NFκB signaling mitigates myocardial injury in a mouse model of arrhythmogenic cardiomyopathy (ACM) expressing a variant in the desmoglein2 gene (Dsg2mut/mut mice). Inflammatory cells are abundant in ACM and likely mediate injury, but cardiac myocytes also mount an immune response in ACM. The relative contributions to cardiac injury of inflammatory cells vs immune activation by cardiac myocytes are not known.