Po-646-01 highly reactive isolevuglandins mediate cytokine-induced electrical remodeling to promote atrial fibrillation

Proinflammatory cytokines have been shown to induce oxidative stress and electrical remodeling. Mice lacking the lymphocyte adaptor protein (Lnk-/-), a negative regulator of cytokine signaling, display systemic and atrial inflammation, oxidative stress, and atrial fibrillation (AF) susceptibility in the absence of structural abnormalities. Previously, we found highly reactive products of lipid peroxidation, isolevuglandins (IsoLGs), to be key mediators of AF susceptibility in Lnk-/- mice.