Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux.

Kushal Saha,Ashwinkumar Subramenium Ganapathy,Alexandra Wang,Nathan Michael Morris,Eric Suchanec,Wei Ding,Gregory Yochum,Walter Koltun, Meghali Nighot,Thomas Ma,Prashant Nighot

Journal of Crohn's & colitis（2023）

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摘要

Our data suggest a novel role of autophagy in promoting the intestinal TJ barrier by increasing occludin levels in an ERK1/2 mitogen-activated protein kinase-dependent mechanism.

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关键词

Autophagy,inflammatory bowel disease,intestinal permeability,occludin,tight junction

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