SESLA suppresses the activation of macrophages and dendritic cells after Gram-positive bacterial challenge.

Xinru Jiang,Yanwu Xu,Tiannan Xiang, Hanxiao Zhang,Xiaodong Cheng,Xiao-Dong Yang,Hongyi Hu,Xin Jiang,Yuejuan Zheng

Immunopharmacology and immunotoxicology（2023）

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摘要

The present study validated the notable anti-inflammatory activity of SESLA and discovered its previously uncharacterized immunoregulatory role and the underlying mechanism in G bacterial infections. Overall, SESLA has a potential to be an antibiotic adjuvant for the treatment of G bacterial infections.

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关键词

Pam3CSK4,Secoeudesma sesquiterpene lactone A (SESLA),inflammatory response,methicillin-resistant Staphylococcus aureus (MRSA),peptidoglycan

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