Detection of soluble suppression of tumorigenicity 2 and N-terminal B-type natriuretic peptide in a rat model of aortic regurgitation: differential responses to omecamtiv mecarbil.

Bachar El Oumeiri,Philippe van de Borne,Géraldine Hubesch,Pascale Jespers,Laurence Dewachter,Constantin Stefanidis,Kathleen Mc Entee,Frédéric Vanden Eynden

Journal of basic and clinical physiology and pharmacology（2022）

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摘要

Because sST2 increased markedly, whereas NT-proBNP remained unchanged, when OM was administered, we hypothesize that sST2 has a distinct capability to detect deleterious effects of passive muscle tension, not reliably assessed by NT-proBNP, in the setting of AR.

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关键词

aortic regurgitation,biomarkers,heart failure,omecamtiv mecarbil,overload

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