Antinociceptive properties of losmapimod in two acute pain models in rats: behavioural analysis, immunohistochemistry, dose response, and comparison with usual analgesic drugs

Mickaël Soued,Leila Hamdi,Mouna Ben Rehouma,Jean-Xavier Mazoit,Dan Benhamou

BJA Open（2022）

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摘要

Losmapimod appears to be a promising drug in severe acute pain conditions. Losmapimod could also be helpful for postoperative pain control, as suggested by its effect after plantar incision.

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关键词

acute pain,antinociceptive drug,losmapimod,p38 inhibition,rodent

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