A sustainable approach for the reliable and simultaneous determination of terpenoids and cannabinoids in hemp inflorescences by vacuum assisted headspace solid-phase microextraction

•Headspace solid phase microextraction can be adopted for the recovery of terpenoids and cannabinoids from Cannabis sativa inflorescences.•Vacuum conditions in the Cannabis headspace ensure the recovery of cannabinoids with low sampling temperature and time.•The adoption of mild conditions allows to not discriminate volatile and semivolatile fractions.•The adoption of mild conditions decreases the formation of artefacts.•The separation of terpenoid and cannabinoids markers can be obtained in less than 30 min with short narrow bore columns.