Intra-arterial Chemotherapy for Retinoblastoma: An Update

Retinoblastoma is the most common primary intraocular tumor in children. It also is one of the most successfully treated tumors using various treatment strategies. Conventional globe salvage treatments include the use of focal therapies in combination with systemic chemotherapy. Intra-arterial chemotherapy (IAC) is a comparatively newer treatment modality used primarily for globe salvage in refractory retinoblastoma. It involves the direct administration of chemotherapy drugs into the ophthalmic artery to achieve a high local intraocular concentration. IAC has been found to successfully treat retinoblastoma, and a few newer modifications are being tried. Our article discusses the significance of IAC, technique employed, drugs used, and newer advances in its administration.