Biomimetic porous hydrogel scaffolds enabled vascular ingrowth and osteogenic differentiation for vascularized tissue-engineered bone regeneration

•The design for vascularized bone regeneration is to fabricate a porous hydrogel scaffold with osteogenic and angiogenic biomimetic microenvironments.•The bone-biomimetic porous hydrogels effectively support the survival, spreading, and osteogenic differentiation of BMSCs.•The bone-biomimetic porous hydrogels have a satisfactory effect on the promotion of vascularized bone regeneration in the ectopic subcutaneous environment.•The bone-biomimetic porous hydrogels successfully repair the skull bone defects in situ.