Polyrotaxane-based multi-step transformable materials for the delivery of Cas9 ribonucleoprotein

Toru Taharabaru,Takuya Kihara,Risako Onodera,Tetsuya Kogo,Kenjirou Higashi,Kunikazu Moribe,Teruya Nakamura,Keiichi Motoyama,Taishi Higashi

Applied Materials Today（2022）

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摘要

•Multi-step transformable materials based on polyrotaxane (amino-PRXs) are developed•Amino-PRXs allow efficient complexation with Cas9 RNP by simple mixing•Multi-step transformable properties of amino-PRXs in the extra/intracellular environments are endowed by step-by-step structural optimization•Fifth generation of amino-PRX is a safe, efficient, and convenient non-viral carrier for Cas9 RNP

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关键词

CRISPR-Cas9,Cas9 RNP,Polyrotaxane,Multi-step transformable supermolecules

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