Bacteria as sensors: Real-time NMR analysis of extracellular metabolites detects sub-lethal amounts of bactericidal molecules released from functionalized materials

Simona Tomaselli,Mariacecilia Pasini,Erika Kozma,Umberto Giovanella,Guido Scavia,Katiuscia Pagano,Henriette Molinari, Salvatore Iannace,Laura Ragona

Biochimica et Biophysica Acta (BBA) - General Subjects（2023）

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摘要

•Bacteria metabolism is a reliable sensor of toxic molecule effective concentration.•NMR indirect observation of toxic molecules detects nanomolar concentrations.•NMR analysis reveals leaking effects from biomedical device.•Developed low-releasing antibacterial silicon material act via contact-killing mechanism.

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关键词

NMR,Metabolite concentration kinetics,Drug release,Antibacterial,Irgasan

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