Multiple lytic bone lesions mimicking Langerhans cell histiocytosis: a case of infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency

Yingyi He,Hui Zhang,Chunjie Li,Xiaoling Su,Wenting Gan,Pengfei Wang,Weiqiang Xiao

Open Forum Infectious Diseases（2022）

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摘要

Abstract We present the first infantile disseminated BCG disease case with STAT1 deficiency, which is manifested by multiple Langerhans cell histiocytosis (LCH) like osteolytic lesions. The diagnosis of BCG-induced osteomyelitis was not initially considered until the additional biopsy revealing the granulomatous inflammation, a key pathological diagnostic component for mycobacterial infection.

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关键词

Langerhans cell histiocytosis,STAT1 mutation,disseminated BCG disease,osteolytic lesions

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