Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen
Organic Letters(2022)
摘要
An open-air method for the transition metal-free direct amination of nitro(hetero)arenes by anilines is disclosed. In this methodology, an aromatic C–H bond is substituted via oxidative nucleophilic aromatic substitution of hydrogen (ONSH). Density functional theory calculations and mechanistic studies support a dianion pathway with oxidation by molecular oxygen as the rate-limiting step.
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关键词
nucleophilic substitution,heteroarenes,hydrogen,nitro-substituted
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