Toxicity by descent: A comparative approach for chemical hazard assessment

John K. Colbourne,Joseph R. Shaw,Elena Sostare,Claudia Rivetti,Romain Derelle, Rosemary Barnett,Bruno Campos,Carlie LaLone,Mark R. Viant,Geoff Hodges

Environmental Advances（2022）

引用 7|浏览12

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摘要

•Pathways to toxicity are shared between humans and other animals by common ancestry.•>70% of adversity-linked genes are shared among distantly related species.•Pathway conservation among species is based on the number of interacting genes.•Biomarkers of adversity are evolutionarily conserved across the animal phylogeny.

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关键词

Evolutionary toxicology,Cross-species extrapolation,Genomics,Model species,Comparative toxicology,Biomarkers

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