A study of the association between polymorphisms in the genes for interleukins IL-6 and IL-10 and negative symptoms subdomains in schizophrenia

Vera Golimbet,Tatyana Lezheiko,Vera Mikhailova,Galina Korovaitseva,Nadezhda Kolesina,Victoria Plakunova,Georgy Kostyuk

Indian Journal of Psychiatry（2022）

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摘要

The results provide further neurobiological evidence for the validity of the NS factor categorization. An imbalance between pro-inflammatory and anti-inflammatory cytokines because of genetic variations is associated with the AA NS subdomain that is supposed to be a more severe aspect of psychopathology compared to the DE.

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关键词

Inflammatory imbalance,negative symptoms heterogeneity,schizophrenia severity

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