Does procalcitonin in septic shock correlate with tissue hypoperfusion and lactate levels?

SESSION TITLE: Sepsis: Beyond 30cc/kg and AntibioticsSESSION TYPE: Rapid Fire Original InvPRESENTED ON: 10/19/2022 11:15 am - 12:15 pmPURPOSE: Septic shock is a leading cause of death in ICUs. Lactic acidosis is common in septic shock due to tissue hypoperfusion. Serum procalcitonin is a marker of infection which is usually elevated in septic shock. Whether serum procalcitonin levels are affected by tissue hypoperfusion is not known. The objective of this study was to determine the relation of serum procalcitonin to tissue hypoperfusion and lactic acidosis in septic shock.METHODS: Medical records of 256 patients admitted to the ICU with septic shock were reviewed. The following data were recorded from medical charts- age, gender, serum procalcitonin and lactate levels at admission, number of patients requiring pressors. Statistical analysis using Pearson’s correlation analysis was used to assess the association between admission serum procalcitonin with admission lactate. p ≤ 0.05 was deemed statistically significant.RESULTS: The mean age of studied subjects was 71.4 ± 15.8 years ; 60% were male. Seventy-five percent required pressors; 51% required mechanical ventilation (MV). Forty percent of patients expired. The mean admission procalcitonin was: 9.9 ± 26.5 ng/ml; mean admission lactate was 6.3 ± 3.3 mmol/L. On correlation analysis, a significant association was noted between admission procalcitonin levels and admission lactate (r=0.176, p= 0.01). However, no significant relation was noted between admission procalcitonin levels and need for pressors (r=0.049, p= 0.4).CONCLUSIONS: Our study indicates that admission serum procalcitonin has a significant correlation with admission lactate level and may have prognostic value in patients with septic shock. Further studies are needed on a larger group of patients to reassess this.CLINICAL IMPLICATIONS: Procalcitonin may have a strong clinical correlation as does lactic acid in septic shock and can possibly help predict severity of hypoperfusion in patients admitted to the ICU with septic shock.DISCLOSURES: No relevant relationships by Nicole BernskoetterNo relevant relationships by Kaamya BhandariNo relevant relationships by Debapriya Datta SESSION TITLE: Sepsis: Beyond 30cc/kg and Antibiotics SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/19/2022 11:15 am - 12:15 pm PURPOSE: Septic shock is a leading cause of death in ICUs. Lactic acidosis is common in septic shock due to tissue hypoperfusion. Serum procalcitonin is a marker of infection which is usually elevated in septic shock. Whether serum procalcitonin levels are affected by tissue hypoperfusion is not known. The objective of this study was to determine the relation of serum procalcitonin to tissue hypoperfusion and lactic acidosis in septic shock. METHODS: Medical records of 256 patients admitted to the ICU with septic shock were reviewed. The following data were recorded from medical charts- age, gender, serum procalcitonin and lactate levels at admission, number of patients requiring pressors. Statistical analysis using Pearson’s correlation analysis was used to assess the association between admission serum procalcitonin with admission lactate. p ≤ 0.05 was deemed statistically significant. RESULTS: The mean age of studied subjects was 71.4 ± 15.8 years ; 60% were male. Seventy-five percent required pressors; 51% required mechanical ventilation (MV). Forty percent of patients expired. The mean admission procalcitonin was: 9.9 ± 26.5 ng/ml; mean admission lactate was 6.3 ± 3.3 mmol/L. On correlation analysis, a significant association was noted between admission procalcitonin levels and admission lactate (r=0.176, p= 0.01). However, no significant relation was noted between admission procalcitonin levels and need for pressors (r=0.049, p= 0.4). CONCLUSIONS: Our study indicates that admission serum procalcitonin has a significant correlation with admission lactate level and may have prognostic value in patients with septic shock. Further studies are needed on a larger group of patients to reassess this. CLINICAL IMPLICATIONS: Procalcitonin may have a strong clinical correlation as does lactic acid in septic shock and can possibly help predict severity of hypoperfusion in patients admitted to the ICU with septic shock. DISCLOSURES: No relevant relationships by Nicole Bernskoetter No relevant relationships by Kaamya Bhandari No relevant relationships by Debapriya Datta