2-(2-Cholesteroxyethoxyl)ethyl-3′-S-glutathionylpropionate (COXP) for brain-targeting liposomes

The blood-brain barrier (BBB) prevents a drug from reaching its therapeutic concentration in the brain resulting in a failure for the treatment of most brain diseases. Various approaches have been explored to develop brain-targeting agents that can help a drug or a drug delivery system to cross the BBB to reach the brain. A ligand or ligand analog of a BBB transporter or BBB receptor has been commonly employed to develop a brain targeting agent.