WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes

M Tuerlings,G M C Janssen, I Boone,M van Hoolwerff,A Rodriguez Ruiz,E Houtman,H E D Suchiman,R J P van der Wal,R G H H Nelissen,R Coutinho de Almeida,P A van Veelen,Y F M Ramos,I Meulenbelt

Osteoarthritis and Cartilage（2023）

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摘要

Mimicking the effect of OA risk allele rs1052429-A on WWP2 expression initiates detrimental processes in the cartilage shown by a response in hypoxia associated genes EPAS1, GDF10, and GJA1 and a decrease in anabolic markers, COL2A1 and ACAN.

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关键词

Osteoarthritis,WWP2,miRNA-140,Articular cartilage

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