[Animal Model Establishment and Its Mechanism of Cytarabine-Iduced Myelosuppression].

Ya-Ling Li,Wei Chu,Jun-Jie Li,Juan-Juan Dong,Gao-Qin Li,Xiao-Jie Jin,Juan Yao,Yong-Qi Liu

Zhongguo shi yan xue ye xue za zhi（2022）

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摘要

Ara-C can induce myelosuppression in mice with a dose-dependent severity and duration, and the model of myelosuppression with Ara-C 100 mg/kg is more optimized. The mechanism is related to the inhibition of BMNC proliferation and the promotion of apoptosis.

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关键词

cytarabine,mouse model,myelosuppression

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