Reference Susceptibility Testing and Genomic Surveillance of Clostridioides difficile, United States, 2012-17.

Amy S Gargis,Maria Karlsson,Ashley L Paulick,Karen F Anderson,Michelle Adamczyk,Nicholas Vlachos,Alyssa G Kent,Gillian McAllister,Susannah L McKay,Alison L Halpin,Valerie Albrecht,Davina Campbell,Lauren C Korhonen,Christopher A Elkins,J Kamile Rasheed,Alice Y Guh,L Clifford McDonald,Joseph D Lutgring

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

Cited 5|Views31

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Abstract

Elevated MICs to antibiotics used for treatment of C. difficile infection were rare, and there was no increase in MICs over time. The lack of vanA/B genes or mutations consistently associated with elevated vancomycin MICs suggests there are multifactorial mechanisms of resistance. Ongoing surveillance of C. difficile using reference AST and WGS to monitor MIC trends and the presence of antibiotic resistance mechanisms is essential.

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Key words

Clostridioides difficile ,agar dilution,antibiotic resistance,metronidazole,vancomycin

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