CircNf1-mediated CXCL12 expression in the spinal cord contributes to morphine analgesic tolerance

Xiaohui Bai,Yongtian Huang,Kun Zhang,Wan Huang,Yanyu Mu,Yujuan Li,Handong Ouyang

Brain, Behavior, and Immunity（2023）

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摘要

•The circRNA to cytokine pathway mediates morphine analgesic tolerance.•CircNf1 functions and increases in the development of morphine analgesic tolerance.•CircNf1 acts as a sponge of miR-330-3p and miR-665 and combines with the promoter of CXCL12, contributing to the CXCL12 expression.

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关键词

Morphine tolerance, Neuroinflammation,Circular RNAs,CXCL12,miRNA sponge

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