Insights into Sickle Cell Disease through the Retinal Microvasculature: Adaptive Optics Scanning Light Ophthalmoscopy Correlates of Clinical OCT Angiography

Alexander Pinhas,Justin V. Migacz,Davis B. Zhou,Maria V. Castanos Toral,Oscar Otero-Marquez, Sharon Israel,Vincent Sun,Peter N. Gillette,Nripun Sredar,Alfredo Dubra,Jeffrey Glassberg,Richard B. Rosen,Toco Y.P. Chui

Ophthalmology Science（2022）

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摘要

Adaptive optics scanning light ophthalmoscopy imaging was able to reveal the cellular details of perfusion abnormalities detected using clinical OCTA. The synergy between these clinical and laboratory imaging modalities presents a promising avenue in the management of SCD through the development of noninvasive ocular biomarkers to prognosticate progression and measure the response to systemic treatment.

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关键词

Adaptive optics,OCT angiography,Oculomics,Retinal microvasculature,Sickle cell disease

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