CD47-SIRPα axis in cancer therapy: Precise delivery of CD47-targeted therapeutics and design of anti-phagocytic drug delivery systems

Junqiao Zhu,Chengyuan Cai,Jiaxin Li,Jisheng Xiao,Xiaopin Duan

Medicine in Drug Discovery（2022）

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摘要

•CD47/SIRPα axis could be a promising therapeutic target•CD47/SIRPα blockade immunotherapy needs targeted delivery.•CD47/SIRPα signal could be exploited for the design of anti-phagocytic DDSs.•Promising DDSs should be able to resist phagocytosis but enhance tumor elimination.

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关键词

CD47-SIRPα axis,Drug delivery systems,Immunotherapy,Anti-phagocytic

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