An expedient synthesis of 3,4-dihydropyrimidin-2(1H)-ones derivatives under solvent free condition using titanium dioxide as a catalyst

Dihydropyrimidones contains pyridine moiety in the ring nucleus. In this work desired product can be prepared in one pot by varying reacting components. Different photocatalysts TiO2, ZnO, ZnS, ZrO2, StO2 were used to carry out reactions to monitor time and yield. Good to excellent results were obtained by using TiO2 as it is nontoxic, inexpensive, mild and reused even after the reaction. Reusability of the catalyst was also depicted in Graph I, nearly three times the catalyst was recycled to obtained more than 50 percent yield. The present methodology showned well tolerance to water content.