Polyvinyl alcohol nanofibers encompass Chitosan/Tripolyphosphate nanogels for controlled release of gemifloxacin antibiotic

To reduce the risk of antibiotics overuse and associated side-effects, development of drug delivery systems (DDS) are necessary. In the present study tripolyphosphate (TPP)/chitosan (CS) nanogels were synthesized and loaded into Polyvinylalcohol (PVA) nanofibers through electrospinning –elctrospraying. The synthesized electrospun scaffolds applied for controlled release of antibiotics e.g. gemifloxacin. For this purpose in the first step Chitosan/Tripolyphosphate (CS/TPP) Nanogels containing antibiotic drugs were synthesized. In the second step the PVA nanofibers were produced using electrospinning while the nanogels were simultaneously electrosprayed on the surface of as-prepared PVA and so the nanofibrous scaffolds including antibiotics loaded nanogels were fabricated (CS/TSS + antibiotics@PVA).