Programmable multicellular and spatially patterned organoids: A one-pot strategy

The simultaneous differentiation of human-induced pluripotent stem cells (hiPSCs) into different cell types is the basis for obtaining organoids and tissues with complex cell components, structures, and functions. Lewis and colleagues' latest work published in Nature Biomedical Engineering presented a new one-pot orthogonally differentiation strategy combined with a multi-material 3D bioprinting method to generate programmatic patterned organoids and bioprinted tissues. This approach will provide a new roadmap to developing engineered tissues for extensive biomedical applications.