Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis

Paul Hiebert, Anastasiya Martyts, Jonas Schwestermann, Katharina Janke,Jürg Hafner,Petra Boukamp,Edoardo Mazza,Sabine Werner

Matrix Biology（2022）

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摘要

•Fibroblasts with activated Nrf2 produce a matrisome similar to aged skin.•Nrf2-mediated changes in ECM promote skin weakening as seen in aging.•Nrf2 regulates hundreds of ECM-suppressing miRNAs in fibroblasts.•High Nrf2 activity in aged human skin may contribute to age-related skin weakening.

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关键词

Aging,Skin mechanics,Extracellular matrix,Nrf2,miRNA,Collagen

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