Lactobacillus GG regulates the Wnt/β-catenin pathway to reinforce intestinal barrier function and alleviate necrotizing enterocolitis

Yang Li,Junfei Chen,Dong Sun,Jingwei Liu,Zhe Wang,Aiwu Li

Journal of Functional Foods（2022）

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摘要

•Intestinal stem cell differentiation is inhibited in NEC mice.•Intestinal barrier function and microbiota are dysregulated in NEC mice.•LGG activates Wnt/β-catenin and improves intestinal barrier function in NEC mice.•Oral LGG feeding can reshape the intestinal flora microenvironment.

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关键词

Lactobacillus,Enterocolitis,Tight junction,Intestine,Microbiota,Wnt/β-catenin

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