Baicalein targets CD36 to prevent foam cell formation by suppressing the excessive uptake of oxLDL and accelerating ABCA1-mediated cholesterol efflux in oxLDL-induced THP-1 macrophages

Jingda Li,Tao Xiong,Tianqi Wang,Meng Wang,Chao Wang,Fuyuan Yang,Xudong Wang,Zhijian Tan,Wenlong Sun

Journal of Functional Foods（2022）

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摘要

•Baicalein can prevent oxLDL-induced foam cell formation in THP-1 macrophages.•Baicalein inhibits oxLDL uptake by preventing the binding of CD36 to oxLDL.•The binding of baicalein to CD36 triggers the Src-JNK-ABCA1 signalling pathway.•Baicalein enhances cholesterol efflux to avoid cholesterol accumulation.

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关键词

Baicalein,CD36,Oxidized low-density lipoprotein,ABCA1,Cholesterol efflux,Macrophage foam cell formation

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