Biometabolites of Tamarindus indica play a remarkable cardioprotective role as a functional food in doxorubicin-induced cardiotoxicity models

Hashi Akter,Md. Mamunur Rashid,Md. Shahidul Islam,Md. Amjad Hossen,Md. Atiar Rahman,Reham M. Algheshairy,Mona S. Almujaydil,Hend F. Alharbi,Afnan M. Alnajeebi

Journal of Functional Foods（2022）

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摘要

•Tamarindus indica is unfolded as a strong antioxidative functional food.•Tamarindus normalized lipid profiles in doxorubicin-induced cardiotoxicity.•Biometabolites-cardiac receptor protein interactions were close to Valsartan.•Heart markers (CK-MB, LDH and Troponin I) were remarkably reduced in cardiac injury.•Cardiac tissue architecture was restored to play a protective role.

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关键词

Tamarindus indica,Cardioprotective activity,Valsartan,Angiotensin type II receptor I,Molecular docking,Histopathological examination

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